Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs

DNA methyltransferase 3A (DNMT3A) mutations occurred in 18%~23% of acute myeloid leukemia (AML) patients, and were considered to be an adverse prognostic factor for adult de novo AML cases. However, the relevant molecular mechanism of the mutation in AML pathogenesis remains obscure. In this study,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yang, Li, Liu, Ya’Nan, Zhang, Na, Ding, Xiao’Yi, Zhang, Wei, Shen, Ke’Feng, Huang, Liang, Zhou, Jian’Feng, Cui, Sen, Zhu, Zun’Min, Hu, Zheng, Xiao, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444751/
https://ncbi.nlm.nih.gov/pubmed/28418922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16449
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