Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients

Covalent modification of protein by drugs may disrupt self-tolerance leading to lymphocyte activation. Determination of the threshold required for this process has not hitherto been possible. We have therefore performed quantitative mass spectrometric analyses to define the epitopes formed in tolera...

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Bibliographic Details
Published in:J Immunol
Main Authors: Meng, Xiaoli, Al-Attar, Zaid, Yaseen, Fiazia S, Jenkins, Rosalind, Earnshaw, Caroline, Whitaker, Paul, Peckham, Daniel, French, Neil S., Naisbitt, Dean J., Park, B Kevin
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444528/
https://ncbi.nlm.nih.gov/pubmed/28438900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700209
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