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Definition of the nature and hapten threshold of the β-lactam antigen required for T cell activation in vitro and in patients

Covalent modification of protein by drugs may disrupt self-tolerance leading to lymphocyte activation. Determination of the threshold required for this process has not hitherto been possible. We have therefore performed quantitative mass spectrometric analyses to define the epitopes formed in tolera...

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Dettagli Bibliografici
Pubblicato in:J Immunol
Autori principali: Meng, Xiaoli, Al-Attar, Zaid, Yaseen, Fiazia S, Jenkins, Rosalind, Earnshaw, Caroline, Whitaker, Paul, Peckham, Daniel, French, Neil S., Naisbitt, Dean J., Park, B Kevin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444528/
https://ncbi.nlm.nih.gov/pubmed/28438900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700209
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