Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

Covalent binding to proteins to form neoantigens is thought to be central to the pathogenesis of penicillin hypersensitivity reactions. We have undertaken detailed mass spectrometric studies to define the mechanism and protein chemistry of hapten formation from benzylpenicillin (BP) and its rearrang...

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Main Authors: Meng, Xiaoli, Jenkins, Rosalind E., Berry, Neil G., Maggs, James L., Farrell, John, Lane, Catherine S., Stachulski, Andrew V., French, Neil S., Naisbitt, Dean J., Pirmohamed, Munir, Park, B. Kevin
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2011
Ábhair:
Toxicology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164351/
https://ncbi.nlm.nih.gov/pubmed/21680886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.183871
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