Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients

Covalent binding to proteins to form neoantigens is thought to be central to the pathogenesis of penicillin hypersensitivity reactions. We have undertaken detailed mass spectrometric studies to define the mechanism and protein chemistry of hapten formation from benzylpenicillin (BP) and its rearrang...

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Detalhes bibliográficos
Main Authors: Meng, Xiaoli, Jenkins, Rosalind E., Berry, Neil G., Maggs, James L., Farrell, John, Lane, Catherine S., Stachulski, Andrew V., French, Neil S., Naisbitt, Dean J., Pirmohamed, Munir, Park, B. Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164351/
https://ncbi.nlm.nih.gov/pubmed/21680886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.183871
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