Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo

1. Sulphamethoxazole has been associated with the occurrence of hypersensitivity reactions. There is controversy as to whether the immune response is metabolism-dependent or -independent. We have therefore investigated the site of antigen formation and the nature of the drug signal presented to the...

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Bibliographische Detailangaben
Hauptverfasser: Naisbitt, Dean J, Gordon, S Fraser, Pirmohamed, Munir, Burkhart, Christoph, Cribb, Alistair E, Pichler, Werner J, Park, B Kevin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2001
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572782/
https://ncbi.nlm.nih.gov/pubmed/11350866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704074
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