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The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole

1Cytochrome P450-mediated bioactivation of sulphamethoxazole to a hydroxylamine has been implicated in the hypersensitivity reactions associated with co-trimoxazole administration. Inhibiting the formation of the hydroxylamine may be one method of preventing the high frequency of toxicity which is o...

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Hlavní autoři: GILL, HELEN J., MAGGS, JAMES L., MADDEN, STEPHEN, PIRMOHAMED, MUNIR, PARK, B. KEVIN
Médium: Artigo
Jazyk:Inglês
Vydáno: 1996
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042677/
https://ncbi.nlm.nih.gov/pubmed/8877026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.40110.x
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