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The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole
1Cytochrome P450-mediated bioactivation of sulphamethoxazole to a hydroxylamine has been implicated in the hypersensitivity reactions associated with co-trimoxazole administration. Inhibiting the formation of the hydroxylamine may be one method of preventing the high frequency of toxicity which is o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2042677/ https://ncbi.nlm.nih.gov/pubmed/8877026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.40110.x |
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