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Drug antigenicity, immunogenicity and co-stimulatory signalling: evidence for formation of a functional antigen through immune cell metabolism
Recognition of drugs by immune cells is usually explained by the hapten model, which states that endogenous metabolites bind irreversibly to protein to stimulate immune cells. Synthetic metabolites interact directly with protein generating antigenic determinants for T-cells; however, experimental ev...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3087426/ https://ncbi.nlm.nih.gov/pubmed/20980635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000889 |
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