Whole-genome fingerprint of the DNA methylome during human B-cell differentiation

We analyzed the DNA methylome of ten subpopulations spanning the entire B-cell differentiation program by whole-genome bisulfite sequencing and high-density microarrays. We observed that non-CpG methylation disappeared upon B-cell commitment whereas CpG methylation changed extensively during B-cell...

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Published in:Nat Genet
Main Authors: Kulis, Marta, Merkel, Angelika, Heath, Simon, Queirós, Ana C., Schuyler, Ronald P., Castellano, Giancarlo, Beekman, Renée, Raineri, Emanuele, Esteve, Anna, Clot, Guillem, Verdaguer-Dot, Nuria, Duran-Ferrer, Martí, Russiñol, Nuria, Vilarrasa-Blasi, Roser, Ecker, Simone, Pancaldi, Vera, Rico, Daniel, Agueda, Lidia, Blanc, Julie, Richardson, David, Clarke, Laura, Datta, Avik, Pascual, Marien, Agirre, Xabier, Prosper, Felipe, Alignani, Diego, Paiva, Bruno, Caron, Gersende, Fest, Thierry, Muench, Marcus O., Fomin, Marina E., Lee, Seung-Tae, Wiemels, Joseph L., Valencia, Alfonso, Gut, Marta, Flicek, Paul, Stunnenberg, Hendrik G., Siebert, Reiner, Küppers, Ralf, Gut, Ivo G., Campo, Elías, Martín-Subero, José I.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444519/
https://ncbi.nlm.nih.gov/pubmed/26053498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3291
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