Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

To investigate the three-dimensional (3D) genome architecture across normal B cell differentiation and in neoplastic cells from different subtypes of chronic lymphocytic leukemia and mantle cell lymphoma patients, here we integrate in situ Hi-C and nine additional omics layers. Beyond conventional a...

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Vydáno v:Nat Commun
Hlavní autoři: Vilarrasa-Blasi, Roser, Soler-Vila, Paula, Verdaguer-Dot, Núria, Russiñol, Núria, Di Stefano, Marco, Chapaprieta, Vicente, Clot, Guillem, Farabella, Irene, Cuscó, Pol, Kulis, Marta, Agirre, Xabier, Prosper, Felipe, Beekman, Renée, Beà, Silvia, Colomer, Dolors, Stunnenberg, Hendrik G., Gut, Ivo, Campo, Elias, Marti-Renom, Marc A., Martin-Subero, José Ignacio
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844026/
https://ncbi.nlm.nih.gov/pubmed/33510161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20849-y
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