Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers

While analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by whole-genome bisulfite sequencing and high-density arrays, we observed a highly heterogeneous pattern globally characterized by regional DNA hypermethylation embedded in extensive hypomethylation. In contrast to t...

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Xehetasun bibliografikoak
Argitaratua izan da:Genome Res
Egile Nagusiak: Agirre, Xabier, Castellano, Giancarlo, Pascual, Marien, Heath, Simon, Kulis, Marta, Segura, Victor, Bergmann, Anke, Esteve, Anna, Merkel, Angelika, Raineri, Emanuele, Agueda, Lidia, Blanc, Julie, Richardson, David, Clarke, Laura, Datta, Avik, Russiñol, Nuria, Queirós, Ana C., Beekman, Renée, Rodríguez-Madoz, Juan R., José-Enériz, Edurne San, Fang, Fang, Gutiérrez, Norma C., García-Verdugo, José M., Robson, Michael I., Schirmer, Eric C., Guruceaga, Elisabeth, Martens, Joost H.A., Gut, Marta, Calasanz, Maria J., Flicek, Paul, Siebert, Reiner, Campo, Elías, Miguel, Jesús F. San, Melnick, Ari, Stunnenberg, Hendrik G., Gut, Ivo G., Prosper, Felipe, Martín-Subero, José I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2015
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381520/
https://ncbi.nlm.nih.gov/pubmed/25644835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.180240.114
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