Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome

Children with Down syndrome (DS) are prone to development of high-risk B-cell precursor ALL (DS-ALL), which differs genetically from most sporadic pediatric ALLs. Increased expression of cytokine receptor-like factor 2 (CRLF2), the receptor to thymic stromal lymphopoietin (TSLP), characterizes about...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Schwartzman, Omer, Savino, Angela Maria, Gombert, Michael, Palmi, Chiara, Cario, Gunnar, Schrappe, Martin, Eckert, Cornelia, von Stackelberg, Arend, Huang, Jin-Yan, Hameiri-Grossman, Michal, Avigad, Smadar, te Kronnie, Geertruy, Geron, Ifat, Birger, Yehudit, Rein, Avigail, Zarfati, Giulia, Fischer, Ute, Mukamel, Zohar, Stanulla, Martin, Biondi, Andrea, Cazzaniga, Giovanni, Vetere, Amedeo, Wagner, Bridget K., Chen, Zhu, Chen, Sai-Juan, Tanay, Amos, Borkhardt, Arndt, Izraeli, Shai
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441776/
https://ncbi.nlm.nih.gov/pubmed/28461505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702489114
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