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DYRK1A in Down syndrome: an oncogene or tumor suppressor?

Children with Down syndrome (DS) have a markedly increased risk of developing acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic leukemia compared with that of children without DS. Despite recent breakthroughs, it is not clear which genes on chromosome 21, the chromosome that is trisomic...

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Detalles Bibliográficos
Main Authors: Birger, Yehudit, Izraeli, Shai
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287238/
https://ncbi.nlm.nih.gov/pubmed/22354166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI62372
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