Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias

Interleukin-7 receptor α (IL7R) is required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency. Here, we describe somatic gain-of-function mutations in IL7R in pediatric B and T acute lymphoblastic leukemias. The mutat...

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Detalhes bibliográficos
Main Authors: Shochat, Chen, Tal, Noa, Bandapalli, Obul R., Palmi, Chiara, Ganmore, Ithamar, te Kronnie, Geertruy, Cario, Gunnar, Cazzaniga, Giovanni, Kulozik, Andreas E., Stanulla, Martin, Schrappe, Martin, Biondi, Andrea, Basso, Giuseppe, Bercovich, Dani, Muckenthaler, Martina U., Izraeli, Shai
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092356/
https://ncbi.nlm.nih.gov/pubmed/21536738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110580
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