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Understanding the contribution of disulfide bridges to the folding and misfolding of an anti‐Aβ scFv
ScFv‐h3D6 is a single chain variable fragment that precludes Aβ peptide‐induced cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway to the worm‐like pathway. Production of scFv molecules is not a straightforward procedure because of the occurrence of disulfide scrambled conformations g...
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| Publicado en: | Protein Sci |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5441429/ https://ncbi.nlm.nih.gov/pubmed/28340507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3164 |
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