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Interrogation of Base Pairing of the Spiroiminodihydantoin Diastereomers Using the α-Hemolysin Latch

Spiroiminodihydantoin (Sp) is a hyperoxidized form of guanine (G) resulting from oxidation by reactive oxygen species (ROS). The lesion is highly mutagenic, and the stereocenter renders the two isomers with distinct behaviors in chemical, spectroscopic, enzymatic, and computational studies. In this...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Zeng, Tao, Fleming, Aaron M., Ding, Yun, White, Henry S., Burrows, Cynthia J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440229/
https://ncbi.nlm.nih.gov/pubmed/28230976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01175
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