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Base Flipping within the α-Hemolysin Latch Allows Single-Molecule Identification of Mismatches in DNA
A method for identifying and differentiating DNA duplexes containing the mismatched base pairs CC and CA at single molecule resolution with the protein pore α-hemolysin (αHL) is presented. Unique modulating current signatures are observed for duplexes containing the CC and CA mismatches when the mis...
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| Publicado en: | J Am Chem Soc |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4828915/ https://ncbi.nlm.nih.gov/pubmed/26704521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b10710 |
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