Systematic mapping of functional enhancer-promoter connections with CRISPR interference

Gene expression in mammals is regulated by noncoding elements that can impact physiology and disease, yet the functions and target genes of most noncoding elements remain unknown. We present a high-throughput approach that uses CRISPR interference (CRISPRi) to discover regulatory elements and identi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Science
Main Authors: Fulco, Charles P., Munschauer, Mathias, Anyoha, Rockwell, Munson, Glen, Grossman, Sharon R., Perez, Elizabeth M., Kane, Michael, Cleary, Brian, Lander, Eric S., Engreitz, Jesse M.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438575/
https://ncbi.nlm.nih.gov/pubmed/27708057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag2445
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