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Thioflavin T fluoresces as excimer in highly concentrated aqueous solutions and as monomer being incorporated in amyloid fibrils

Fluorescence of thioflavin T (ThT) is a proven tool for amyloid fibrils study. The correct model of ThT binding to fibrils is crucial to clarify amyloid fibrils structure and mechanism of their formation. Although there are convincing evidences that ThT has molecular rotor nature, implying it’s bind...

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Publicat a:Sci Rep
Autors principals: Sulatskaya, Anna I., Lavysh, Andrey V., Maskevich, Alexander A., Kuznetsova, Irina M., Turoverov, Konstantin K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438369/
https://ncbi.nlm.nih.gov/pubmed/28526838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02237-7
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