Destabilization of the TWIST1/E12 complex dimerization following the R154P point-mutation of TWIST1: an in silico approach

BACKGROUND: The bHLH transcription factor TWIST1 plays a key role in the embryonic development and in tumorigenesis. Some loss-of-function mutations of the TWIST1 gene have been shown to cause an autosomal dominant craniosynostosis, known as the Saethre-Chotzen syndrome (SCS). Although the functiona...

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Detaylı Bibliyografya
Yayımlandı:BMC Struct Biol
Asıl Yazarlar: Bouard, Charlotte, Terreux, Raphael, Tissier, Agnès, Jacqueroud, Laurent, Vigneron, Arnaud, Ansieau, Stéphane, Puisieux, Alain, Payen, Léa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437649/
https://ncbi.nlm.nih.gov/pubmed/28521820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12900-017-0076-x
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