Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity

Metformin is the first-line drug in the treatment of type 2 diabetes. In addition to its hypoglycemic effect, metformin has an anti-inflammatory function, but the precise mechanism promoting this activity remains unclear. High mobility group box 1 (HMGB1) is an alarmin that is released from necrotic...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Horiuchi, Takahiro, Sakata, Natsumi, Narumi, Yoshihiro, Kimura, Tomohiro, Hayashi, Takashi, Nagano, Keisuke, Liu, Keyue, Nishibori, Masahiro, Tsukita, Sohei, Yamada, Tetsuya, Katagiri, Hideki, Shirakawa, Ryutaro, Horiuchi, Hisanori
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437248/
https://ncbi.nlm.nih.gov/pubmed/28373282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.769380
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