Prostaglandin E(2) inhibits neutrophil extracellular trap formation through production of cyclic AMP

BACKGROUND AND PURPOSE: Upon stimulation, neutrophils release their nuclear contents called neutrophil extracellular traps (NETs), which contain unfolded chromatin and lysosomal enzymes. NETs have been demonstrated to play a critical role in host defence, although the role of PGE(2), a bioactive sub...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Autores principales: Shishikura, Kyosuke, Horiuchi, Takahiro, Sakata, Natsumi, Trinh, Duc‐Anh, Shirakawa, Ryutaro, Kimura, Tomohiro, Asada, Yujiro, Horiuchi, Hisanori
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341226/
https://ncbi.nlm.nih.gov/pubmed/26505736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13373
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