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Physiological and pathological roles of the γ-secretase complex
Gamma-secretase (GS) is an enzyme complex that cleaves numerous substrates, and it is best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ peptides. Aberrant cleavage of APP can lead to Alzheimer’s disease, so much research has been done to better understand GS structure...
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| Publié dans: | Brain Res Bull |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5436903/ https://ncbi.nlm.nih.gov/pubmed/27133790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainresbull.2016.04.019 |
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