The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria

Pyruvate kinase (PKLR) deficiency protects mice and humans against blood-stage malaria. Although mouse strain AcB62 carries a malaria-protective Pklr(I90N) genetic mutation, it is phenotypically susceptible to blood stage malaria induced by infection with Plasmodium chabaudi AS, suggesting a genetic...

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Udgivet i:PLoS One
Main Authors: Laroque, Aurélie, Min-Oo, Gundula, Tam, Mifong, Ponka, Prem, Stevenson, Mary M., Gros, Philippe
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436716/
https://ncbi.nlm.nih.gov/pubmed/28542307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177818
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