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The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria
Pyruvate kinase (PKLR) deficiency protects mice and humans against blood-stage malaria. Although mouse strain AcB62 carries a malaria-protective Pklr(I90N) genetic mutation, it is phenotypically susceptible to blood stage malaria induced by infection with Plasmodium chabaudi AS, suggesting a genetic...
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| 發表在: | PLoS One |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5436716/ https://ncbi.nlm.nih.gov/pubmed/28542307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177818 |
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