IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice

Severe asthma (SA) is a significant problem both clinically and economically, given its poor response to corticosteroids (CS). We recently reported a complex type 1–dominated (IFN-γ–dominated) immune response in more than 50% of severe asthmatics despite high-dose CS treatment. Also, IFN-γ was found...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Oriss, Timothy B., Raundhal, Mahesh, Morse, Christina, Huff, Rachael E., Das, Sudipta, Hannum, Rachel, Gauthier, Marc C., Scholl, Kathryn L., Chakraborty, Krishnendu, Nouraie, Seyed M., Wenzel, Sally E., Ray, Prabir, Ray, Anuradha
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436536/
https://ncbi.nlm.nih.gov/pubmed/28515358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91019
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