IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice

Severe asthma (SA) is a significant problem both clinically and economically, given its poor response to corticosteroids (CS). We recently reported a complex type 1–dominated (IFN-γ–dominated) immune response in more than 50% of severe asthmatics despite high-dose CS treatment. Also, IFN-γ was found...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Oriss, Timothy B., Raundhal, Mahesh, Morse, Christina, Huff, Rachael E., Das, Sudipta, Hannum, Rachel, Gauthier, Marc C., Scholl, Kathryn L., Chakraborty, Krishnendu, Nouraie, Seyed M., Wenzel, Sally E., Ray, Prabir, Ray, Anuradha
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436536/
https://ncbi.nlm.nih.gov/pubmed/28515358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91019
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