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Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias

We previously showed that Th1/type 1 inflammation marked by increased IFN-γ levels in the airways can be appreciated in 50% of patients with severe asthma, despite high dose corticosteroid (CS) treatment. We hypothesized that a downstream target of IFN-γ, CXCL10, which recruits Th1 cells via the cog...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:JCI Insight
Main Authors: Gauthier, Marc, Chakraborty, Krishnendu, Oriss, Timothy B., Raundhal, Mahesh, Das, Sudipta, Chen, Jie, Huff, Rachael, Sinha, Ayan, Fajt, Merritt, Ray, Prabir, Wenzel, Sally E., Ray, Anuradha
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499373/
https://ncbi.nlm.nih.gov/pubmed/28679952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94580
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