Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias

We previously showed that Th1/type 1 inflammation marked by increased IFN-γ levels in the airways can be appreciated in 50% of patients with severe asthma, despite high dose corticosteroid (CS) treatment. We hypothesized that a downstream target of IFN-γ, CXCL10, which recruits Th1 cells via the cog...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Gauthier, Marc, Chakraborty, Krishnendu, Oriss, Timothy B., Raundhal, Mahesh, Das, Sudipta, Chen, Jie, Huff, Rachael, Sinha, Ayan, Fajt, Merritt, Ray, Prabir, Wenzel, Sally E., Ray, Anuradha
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499373/
https://ncbi.nlm.nih.gov/pubmed/28679952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94580
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