Acute inactivation of the replicative helicase in human cells triggers MCM8–9-dependent DNA synthesis

DNA replication fork progression can be disrupted at difficult to replicate loci in the human genome, which has the potential to challenge chromosome integrity. This replication fork disruption can lead to the dissociation of the replisome and the formation of DNA damage. To model the events stemmin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genes Dev
Egile Nagusiak: Natsume, Toyoaki, Nishimura, Kohei, Minocherhomji, Sheroy, Bhowmick, Rahul, Hickson, Ian D., Kanemaki, Masato T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2017
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435893/
https://ncbi.nlm.nih.gov/pubmed/28487407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.297663.117
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