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Inhibiting the MCM8‐9 complex selectively sensitizes cancer cells to cisplatin and olaparib
MCM8 and MCM9 are paralogues of the MCM2‐7 eukaryotic DNA replication helicase proteins and play a crucial role in a homologous recombination‐mediated repair process to resolve replication stress by fork stalling. Thus, deficiency of MCM8‐9 sensitizes cells to replication stress caused, for example,...
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| 發表在: | Cancer Sci |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
John Wiley and Sons Inc.
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6398883/ https://ncbi.nlm.nih.gov/pubmed/30648820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13941 |
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