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Acute inactivation of the replicative helicase in human cells triggers MCM8–9-dependent DNA synthesis
DNA replication fork progression can be disrupted at difficult to replicate loci in the human genome, which has the potential to challenge chromosome integrity. This replication fork disruption can lead to the dissociation of the replisome and the formation of DNA damage. To model the events stemmin...
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| 發表在: | Genes Dev |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5435893/ https://ncbi.nlm.nih.gov/pubmed/28487407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.297663.117 |
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