Phosphorylation of MCM4 at Sites Inactivating DNA Helicase Activity of the MCM4-MCM6-MCM7 Complex during Epstein-Barr Virus Productive Replication

Induction of Epstein-Barr virus (EBV) lytic replication blocks chromosomal DNA replication notwithstanding an S-phase-like cellular environment with high cyclin-dependent kinase (CDK) activity. We report here that the phosphorylated form of MCM4, a subunit of the MCM complex essential for chromosoma...

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Auteurs principaux: Kudoh, Ayumi, Daikoku, Tohru, Ishimi, Yukio, Kawaguchi, Yasushi, Shirata, Noriko, Iwahori, Satoko, Isomura, Hiroki, Tsurumi, Tatsuya
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2006
Sujets:
Genome Replication and Regulation of Viral Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617282/
https://ncbi.nlm.nih.gov/pubmed/17005684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00678-06
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