Inhibition of S-Phase Cyclin-Dependent Kinase Activity Blocks Expression of Epstein-Barr Virus Immediate-Early and Early Genes, Preventing Viral Lytic Replication

The induction of lytic replication of the Epstein-Barr virus (EBV) completely arrests cell cycle progression, in spite of elevation of S-phase cyclin-dependent kinase (CDK) activity, thereby causing accumulation of hyperphosphorylated forms of retinoblastoma (Rb) protein (A. Kudoh, M. Fujita, T. Kiy...

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Main Authors: Kudoh, Ayumi, Daikoku, Tohru, Sugaya, Yutaka, Isomura, Hiroki, Fujita, Masatoshi, Kiyono, Tohru, Nishiyama, Yukihiro, Tsurumi, Tatsuya
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC303396/
https://ncbi.nlm.nih.gov/pubmed/14671092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.1.104-115.2004
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