Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity

Post-translational modification by SUMO (small ubiquitin-like modifier) plays important but still poorly understood regulatory roles in eukaryotic cells, including as a signal for ubiquitination by SUMO targeted ubiquitin ligases (STUbLs). Here, we delineate the molecular mechanisms for SUMO-depende...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genes Dev
Main Authors: Liang, Jason, Singh, Namit, Carlson, Christopher R., Albuquerque, Claudio P., Corbett, Kevin D., Zhou, Huilin
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435892/
https://ncbi.nlm.nih.gov/pubmed/28487408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.296145.117
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