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A Simple Combinatorial Codon Mutagenesis Method for Targeted Protein Engineering

Directed evolution is a powerful tool for optimizing enzymes, and mutagenesis methods that improve enzyme library quality can significantly expedite the evolution process. Here, we report a simple method for targeted combinatorial codon mutagenesis (CCM). To demonstrate the utility of this method fo...

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Detalhes bibliográficos
Publicado no:ACS Synth Biol
Main Authors: Belsare, Ketaki D., Andorfer, Mary C., Cardenas, Frida, Chael, Julia, Park, Hyun June, Lewis, Jared C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435451/
https://ncbi.nlm.nih.gov/pubmed/28033708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.6b00297
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