Engineering multiple properties of a protein by combinatorial mutagenesis.
A method for simultaneously engineering multiple properties of a protein, based on the observed additivity of effects of individual mutations, is presented. We show that, for the gene V protein of bacteriophage f1, effects of double mutations on both protein stability and DNA binding affinity are ap...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47357/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8378307/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.18.8367 |
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