SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis

Alveolar epithelial cell (AEC) mitochondrial dysfunction and apoptosis are important in idiopathic pulmonary fibrosis and asbestosis. Sirtuin 3 (SIRT3) detoxifies mitochondrial reactive oxygen species, in part, by deacetylating manganese superoxide dismutase (MnSOD) and mitochondrial 8-oxoguanine DN...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Jablonski, Renea P., Kim, Seok-Jo, Cheresh, Paul, Williams, David B., Morales-Nebreda, Luisa, Cheng, Yuan, Yeldandi, Anjana, Bhorade, Sangeeta, Pardo, Annie, Selman, Moises, Ridge, Karen, Gius, David, Budinger, G. R. Scott, Kamp, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434657/
https://ncbi.nlm.nih.gov/pubmed/28258190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601077R
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