Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy

HIV and SIV infection dynamics are commonly investigated by measuring plasma viral loads. However, this total viral load value represents the sum of many individual infection events, which are difficult to independently track using conventional sequencing approaches. To overcome this challenge, we g...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Fennessey, Christine M., Pinkevych, Mykola, Immonen, Taina T., Reynaldi, Arnold, Venturi, Vanessa, Nadella, Priyanka, Reid, Carolyn, Newman, Laura, Lipkey, Leslie, Oswald, Kelli, Bosche, William J., Trivett, Matthew T., Ohlen, Claes, Ott, David E., Estes, Jacob D., Del Prete, Gregory Q., Lifson, Jeffrey D., Davenport, Miles P., Keele, Brandon F.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5433785/
https://ncbi.nlm.nih.gov/pubmed/28472156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006359
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