Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus

The selective pressures acting on viruses that replicate under enhanced mutation rates are largely unknown. Here, we describe resistance of foot-and-mouth disease virus to the mutagen 5-fluorouracil (FU) through a single polymerase substitution that prevents an excess of A to G and U to C transition...

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Veröffentlicht in:Genome Biol Evol
Hauptverfasser: de la Higuera, Ignacio, Ferrer-Orta, Cristina, de Ávila, Ana I., Perales, Celia, Sierra, Macarena, Singh, Kamalendra, Sarafianos, Stefan G., Dehouck, Yves, Bastolla, Ugo, Verdaguer, Nuria, Domingo, Esteban
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5433387/
https://ncbi.nlm.nih.gov/pubmed/28460010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evx075
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