Metreleptin Therapy Lowers Plasma Angiopoietin-like protein 3 (ANGPTL3) in Patients with Generalized Lipodystrophy

BACKGROUND: Reduced triglyceride clearance due to impaired lipoprotein lipase (LPL)-mediated lipolysis contributes to severe hypertriglyceridemia in lipodystrophy. Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) impair clearance of triglycerides by inhibiting LPL. Whether circulating ANGPTL3/4...

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Publicado en:J Clin Lipidol
Autores principales: Muniyappa, Ranganath, Abel, Brent S., Asthana, Asha, Walter, Mary F., Cochran, Elaine K., Remaley, Alan T., Skarulis, Monica C., Gorden, Phillip, Brown, Rebecca J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5433252/
https://ncbi.nlm.nih.gov/pubmed/28502512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacl.2017.02.002
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