Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

In this study, we evaluated the consequences of reducing Galectin-1 (Gal-1) in the tumor micro-environment (TME) of glioblastoma multiforme (GBM), via nose-to-brain transport. Gal-1 is overexpressed in GBM and drives chemo- and immunotherapy resistance. To promote nose-to-brain transport, we designe...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Van Woensel, Matthias, Mathivet, Thomas, Wauthoz, Nathalie, Rosière, Rémi, Garg, Abhishek D., Agostinis, Patrizia, Mathieu, Véronique, Kiss, Robert, Lefranc, Florence, Boon, Louis, Belmans, Jochen, Van Gool, Stefaan W., Gerhardt, Holger, Amighi, Karim, De Vleeschouwer, Steven
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430862/
https://ncbi.nlm.nih.gov/pubmed/28450700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01279-1
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