Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

In this study, we evaluated the consequences of reducing Galectin-1 (Gal-1) in the tumor micro-environment (TME) of glioblastoma multiforme (GBM), via nose-to-brain transport. Gal-1 is overexpressed in GBM and drives chemo- and immunotherapy resistance. To promote nose-to-brain transport, we designe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Van Woensel, Matthias, Mathivet, Thomas, Wauthoz, Nathalie, Rosière, Rémi, Garg, Abhishek D., Agostinis, Patrizia, Mathieu, Véronique, Kiss, Robert, Lefranc, Florence, Boon, Louis, Belmans, Jochen, Van Gool, Stefaan W., Gerhardt, Holger, Amighi, Karim, De Vleeschouwer, Steven
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430862/
https://ncbi.nlm.nih.gov/pubmed/28450700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01279-1
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