Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?

Despite recent advances in tumor imaging and chemoradiotherapy, the median overall survival of patients diagnosed with glioblastoma multiforme does not exceed 15 months. Infiltration of glioma cells into the brain parenchyma, and the blood-brain barrier are important hurdles to further increase the...

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Bibliografske podrobnosti
Main Authors: Stefaan W. van Gool, Steven de Vleeschouwer, Florence Lefranc, Véronique Mathieu, Rémi Rosière, Karim Amighi, Matthias van Woensel, Nathalie Wauthoz
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2013-08-01
Serija:Cancers
Teme:
glioblastoma multiforme
intranasal administration
nose-to-brain delivery
formulations
nanoparticles
drug delivery
new therapy concept
Online dostop:http://www.mdpi.com/2072-6694/5/3/1020
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