Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

In this study, we evaluated the consequences of reducing Galectin-1 (Gal-1) in the tumor micro-environment (TME) of glioblastoma multiforme (GBM), via nose-to-brain transport. Gal-1 is overexpressed in GBM and drives chemo- and immunotherapy resistance. To promote nose-to-brain transport, we designe...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Van Woensel, Matthias, Mathivet, Thomas, Wauthoz, Nathalie, Rosière, Rémi, Garg, Abhishek D., Agostinis, Patrizia, Mathieu, Véronique, Kiss, Robert, Lefranc, Florence, Boon, Louis, Belmans, Jochen, Van Gool, Stefaan W., Gerhardt, Holger, Amighi, Karim, De Vleeschouwer, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430862/
https://ncbi.nlm.nih.gov/pubmed/28450700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01279-1
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