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Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

In this study, we evaluated the consequences of reducing Galectin-1 (Gal-1) in the tumor micro-environment (TME) of glioblastoma multiforme (GBM), via nose-to-brain transport. Gal-1 is overexpressed in GBM and drives chemo- and immunotherapy resistance. To promote nose-to-brain transport, we designe...

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Bibliografske podrobnosti
izdano v:	Sci Rep
Main Authors:	Van Woensel, Matthias, Mathivet, Thomas, Wauthoz, Nathalie, Rosière, Rémi, Garg, Abhishek D., Agostinis, Patrizia, Mathieu, Véronique, Kiss, Robert, Lefranc, Florence, Boon, Louis, Belmans, Jochen, Van Gool, Stefaan W., Gerhardt, Holger, Amighi, Karim, De Vleeschouwer, Steven
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group UK 2017
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5430862/ https://ncbi.nlm.nih.gov/pubmed/28450700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01279-1
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Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

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