Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake

Huperzine A (Hup-A) is a poorly water-soluble drug with low oral bioavailability. A self-microemulsifying drug delivery system (SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion (SPIP) technique and a chylomicron flow...

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Publicado en:Acta Pharm Sin B
Autores principales: Li, Fang, Hu, Rongfeng, Wang, Bin, Gui, Yun, Cheng, Gang, Gao, Song, Ye, Lei, Tang, Jihui
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430757/
https://ncbi.nlm.nih.gov/pubmed/28540173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2017.02.002
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