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Therapeutic targeting using tumor specific peptides inhibits long non-coding RNA HOTAIR activity in ovarian and breast cancer

Long non-coding RNAs (lncRNAs) play key roles in human diseases, including cancer. Functional studies of the lncRNA HOTAIR (HOX transcript antisense RNA) provide compelling evidence for therapeutic targeting of HOTAIR in cancer, but targeting lncRNAs in vivo has proven to be difficult. In the curren...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Özeş, Ali R., Wang, Yinu, Zong, Xingyue, Fang, Fang, Pilrose, Jay, Nephew, Kenneth P.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429858/
https://ncbi.nlm.nih.gov/pubmed/28420874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00966-3
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