NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer

The transcription factor nuclear factor kappa B (NF-κB) and the long non-coding RNA (lncRNA) HOTAIR (HOX transcript antisense RNA) play diverse functional roles in cancer. In this study, we show that upregulation of HOTAIR induced platinum resistance in ovarian cancer, and increased HOTAIR levels we...

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Udgivet i:Oncogene
Main Authors: Özeş, Ali R., Miller, David F., Özeş, Osman N., Fang, Fang, Liu, Yunlong, Matei, Daniela, Huang, Tim, Nephew, Kenneth P.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050052/
https://ncbi.nlm.nih.gov/pubmed/27041570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.75
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