The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be assisted by host cell factors. Here we investigate...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Schuster, Manuel, Schnell, Leonie, Feigl, Peter, Birkhofer, Carina, Mohr, Katharina, Roeder, Maurice, Carle, Stefan, Langer, Simon, Tippel, Franziska, Buchner, Johannes, Fischer, Gunter, Hausch, Felix, Frick, Manfred, Schwan, Carsten, Aktories, Klaus, Schiene-Fischer, Cordelia, Barth, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429619/
https://ncbi.nlm.nih.gov/pubmed/28377614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00780-x
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