The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be assisted by host cell factors. Here we investigate...

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Published in:Sci Rep
Main Authors: Schuster, Manuel, Schnell, Leonie, Feigl, Peter, Birkhofer, Carina, Mohr, Katharina, Roeder, Maurice, Carle, Stefan, Langer, Simon, Tippel, Franziska, Buchner, Johannes, Fischer, Gunter, Hausch, Felix, Frick, Manfred, Schwan, Carsten, Aktories, Klaus, Schiene-Fischer, Cordelia, Barth, Holger
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429619/
https://ncbi.nlm.nih.gov/pubmed/28377614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00780-x
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