PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells

RNA-binding proteins (RBPs) have emerged as important regulators of invertebrate adult stem cells, but their activities remain poorly appreciated in mammals. Using a short hairpin RNA strategy, we demonstrate here that the 2 mammalian RBPs, PUMILIO (PUM)1 and PUM2, members of the PUF family of postt...

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Publicado en:Blood
Autores principales: Naudin, Cécile, Hattabi, Aurore, Michelet, Fabio, Miri-Nezhad, Ayda, Benyoucef, Aissa, Pflumio, Françoise, Guillonneau, François, Fichelson, Serge, Vigon, Isabelle, Dusanter-Fourt, Isabelle, Lauret, Evelyne
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2017
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429137/
https://ncbi.nlm.nih.gov/pubmed/28232582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-747436
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