HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4

BACKGROUND: Expansion of hematopoietic stem cells represents an important objective for improving cell and gene therapy protocols. Retroviral transduction of the HoxB4 homeogene in mouse and human hematopoietic stem cells and hematopoietic progenitors is known to promote the cells’ expansion. A safe...

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Bibliographic Details
Main Authors: Auvray, Céline, Delahaye, Andrée, Pflumio, Françoise, Haddad, Rima, Amsellem, Sophie, Miri-Nezhad, Ayda, Broix, Loïc, Yacia, Azzedine, Bulle, Frédérique, Fichelson, Serge, Vigon, Isabelle
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2012
Subjects:
Original Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269473/
https://ncbi.nlm.nih.gov/pubmed/22298821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.051235
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